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A Buffalo chicken burger with cheese, ranch, tomato and lettuce on a wooden cutting board

Buffalo Chicken Breast Burgers

No ordinary chicken burger, these Buffalo chicken burgers are tender, juicy, spicy and packed with flavor! 
Course Main Dish
Cuisine American
Prep Time 5 minutes
Cook Time 25 minutes
Total Time 30 minutes
Servings 4 burgers
Calories 532kcal
Author Ann Otis


  • 4 small skinless boneless chicken breasts
  • salt and pepper to taste
  • 1/2 cup all-purpose flour
  • 1 tablespoon olive oil
  • 1/2 cup cayenne pepper hot sauce such as Frank's Red Hot
  • 1 tablespoon butter melted
  • 4 burger buns
  • ranch or blue cheese to taste
  • 4 slices provolone or mozzarella
  • optional toppings: lettuce, tomato, red onion


  • Preheat the oven to 400 degrees F. Using a meat mallet or heavy rolling pin, pound the chicken breasts a bit, just to even out the thickness.* 
  • Heat the olive oil in a large oven-safe pan (cast iron is ideal) over medium-high heat.
  • Sprinkle the flour on a plate or shallow dish. Season the chicken breasts with salt and pepper and dredge in the flour, shaking off the excess.
  • Add chicken breasts to the hot pan and sear for about 2 minutes on each side, until golden brown.
  • While the chicken is searing, stir together the hot sauce and melted butter. Pour sauce over the chicken breasts and transfer the pan to the oven. (Note: if your pan is not oven safe, transfer the chicken breasts to a baking dish before pouring on the sauce and placing in the oven)
  • Bake chicken breasts for 20-25 minutes, until just cooked through. Add cheese slices to the tops and return to the oven to melt for a minute or two.
  • Top each burger bun with a chicken breast, ranch or blue cheese dressing, and additional toppings of your choice.


*After I've pounded the chicken breasts a bit, I also like to slice off the chicken tenders (small dangly part) and trim them to a roundish shape to fit the buns better, but this is totally optional. I freeze the trimmings to use in soups and such.


Calories: 532kcal | Carbohydrates: 35g | Protein: 37g | Fat: 26g | Saturated Fat: 9g | Cholesterol: 104mg | Sodium: 1700mg | Potassium: 537mg | Fiber: 1g | Sugar: 3g | Vitamin A: 370IU | Vitamin C: 2.4mg | Calcium: 296mg | Iron: 2.9mg